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Type Psychoactive
Legal Status Class B
MDPV (Methylenedioxypyrovalerone) is structurally similar to mephedrone (4-methylmethcathinone). Synthetic cathinones are usually insufflated, and/or taken orally or in solution, but are also be taken intravenously.
Preliminary experience is that toxicity resembles that of amphetamines, although the duration of effects may be more prolonged. Clinical effects may include tachycardia, palpitations, anxiety, agitation, excessive sweating, headache, nausea, or hypertension. Convulsions, hallucinations, raised creatine kinase, chest pain, skin rashes and peripheral vasoconstriction have also been reported in some users. Nasal irritation and epistaxis may occur after nasal insufflation. Serotonin syndrome may occur, this is more likely to occur if an individual has been exposed to two or more drugs that increase the effect of serotonin in serotonergic synapses (by increasing release, reducing reuptake or metabolism, or stimulating serotonin receptors), either as an acute overdose or if taken regularly, for example - SSRIs, SNRIs, MAOIs, tricyclic antidepressants, tramadol, triptans, linezolid and St John's Wort; stimulant drugs (e.g. MDMA (ecstasy), amphetamines, cocaine, cathinone derivatives (mephedrone, etc)).
Short Term Effects
Limited information is available on the effects of synthetic cathinones. Users often repeat dosing over short periods of time to maintain pleasurable effects. Synthetic cathinones may cause euphoria, increase alertness, intensify emotions and boost self-esteem.