WEDINOS -  Home
WEDINOS DAN 24/7 Public Health Wales Welsh Government Naloxone saves lives

Amphetamine

Type Psychoactive
Legal Status Class B
Amphetamine
Amphetamine is a sympathomimetic phenethylamine derivative with prominent central stimulant activity. As a street drug, amphetamine usually comes as a white, grey, yellowish or pinky powder or as putty-like substance known as base. - Swallowing / Bombing : Stimulant drugs are caustic and can corrode soft tissues. This may result in damage to the lining of the throat, oesophagus and stomach. Ingest within a capsule/cigarette paper - Try not to inject . Injecting amphetamine can be compulsive. If you do inject – Don’t share equipment, ensure enough needles for repeat injections. Amphetamine is usually low purity, and if injected should be filtered carefully. - Try not to use other drugs, such as benzodiazepines, to come down. The come down will pass without using more drugs. - Know the importance of nutrition and hydration. Amphetamines are appetite suppressants and can cause the body to overheat and sweat. - Amphetamine use can cause you to grind your teeth and jaws. Chew gum to help avoid tooth damage. - The use of stimulant drugs has become very popular; using more than one stimulant drug at a time drug can put your heart under significant stress. - Do not mix amphetamines with monoamine oxidase inhibitors (MAOIs), they include: moclobemide, phenelzine, isocarboxazid and tranylcypromine and come in various different brand names. - Make sure you have more days where you don’t use, than days that you use. - Use in a safe environment with trusted company - Tell someone you are with what you are taking
Toxicity
There are reports of fatalities having resulted from the acute oral or intraveneous administration of amphetamine. Death does not usually ensue immediately but after a period of several hours, during which the subject experiences agitation, hyperthermia, convulsions, unconsciousness, and respiratory and/or cardiac failure (Disposition of toxic drugs and chemicals in man, Baselt, R.C). The acute lethal dose of amphetamine in adults has been reported to be 20-25 mg/kg (Zalis and Parmley, 1963) but individual response varies greatly due to tolerance, and toxicity correlates poorly with the amount taken. Serotonin syndrome may occur, this is more likely to occur if an individual has been exposed to two or more drugs that increase the effect of serotonin in serotonergic synapses (by increasing release, reducing reuptake or metabolism, or stimulating serotonin receptors), either as an acute overdose or if taken regularly, for example - SSRIs, SNRIs, MAOIs, tricyclic antidepressants, tramadol, triptans, linezolid and St John's Wort; stimulant drugs (e.g. MDMA (ecstasy), amphetamines, cocaine, cathinone derivatives (mephedrone, etc)).
Addiction Potential
Amphetamines induce psychological dependence.
Short Term Effects
Amphetamine may induce effects of euphoria, alertness, increased energy, appetite suppression increased alertness & mental clarity, and may also intensify emotions and boost self-esteem. In addition amphetmaines may cause tremor, sweating, dilated pupils, agitation, confusion, headache, anxiety, vomiting, abdominal pain, seizures, hallucinations or delusions. Chest pain, palpitations, dyspnoea, systemic hypotension or hypertension may occur. Narrow-complex tachycardias are common; ventricular tachycardia or ventricular fibrillation may occur. Hyperpyrexia may be severe. Metabolic acidosis may also occur.
Long Term Effects
Psychosis, psychological dependence