|Legal Status||To be confirmed|
An antidepressant which acts as a pre-synaptic alpha2-antagonist, which increases central noradrenergic and serotinergic neurotransmission. It also acts as an H1 histamine antagonist; this accounts for its sedative effects which are prominent in overdose.
|Short Term Effects||
The most common effect following ingestion is sedation. Other features may include nausea, vomiting, headache, tremor, miosis, disorientation, ataxia, tachycardia, bradycardia and hypotension. Rhabdomyolysis has been reported. Effects on the central nervous system may be enhanced or prolonged following co-ingestion of other central nervous system depressants, including alcohol.
Identified in Sweden: 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one (norfludiazepam). Norfludiazepam is a benzodiazepine and is structurally related to the internationally controlled substance diazepam.
Alert: Please be advised that Public Health England have issued an alert re. Fentanyl following identification post-mortem of fentanyl and heroin. This alert advises of the availability of, and harms from, heroin that has been mixed with fentanyl or carfentanyl, both unusually potent synthetic opioids. Those in contact with heroin users should be alert to the increased possibility of overdose arising from heroin cut with these synthetic opioids, be able to recognise possible symptoms of overdose and respond appropriately.